I look at it this way, cash game 100BB defending vs CO is 22+, T9o+, suited connectors, K2s+, Q7s+, A2o+, naturally at 30-60bb I'd narrow those down a bit and expand/narrow depending on the raiser's position. It also depends on your confidence in playing those hands postflop. Personally, I tend to be on the nittier side, since I feel my edge comes from short stack play and heads-up. Therefore, when I play a hand, I should have a range advantage (which tbh has happened pretty frequently as villains tend to play too loose, with weaker Ax and Kx). Re 2x vs 2.5x, I generally wouldn't consider them differently unless I have specific reads on villains. Yes, you obviously do get better odds vs 2x, but nowadays smaller raises are more frequent, so I don't adjust too much my ranges (although I am aware of the counter arguments). Personally I 2x 80% of the time, the rest being mostly isolating specific villains which I consider calling stations, with stronger holdings and a very small percentage of limping for set mining. So far I've only done ~130 games, trying to do 30 per day 6 tabling x 5 mini sessions :) But I think my winrate comes a lot from winning HU games all in all.